@article {Simula.simula.3028,
	title = {Calcium Signaling in Developing Cardiomyocytes: Implications for Model Systems and Disease},
	journal = {The Journal of Physiology},
	volume = {593},
	year = {2015},
	month = {03/2015},
	pages = {1047-1063},
	publisher = {John Wiley and Sons},
	abstract = {Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca2+ sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca2+ homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as neonatal cell culture and stem cells.},
	doi = {10.1113/jphysiol.2014.274712},
	url = {http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.274712/abstract},
	author = {William E. {Louch} and Koivum{\"a}ki, Jussi and Tavi, Pasi}
}
