@article {Simula.simula.1594,
	title = {Improved Discretisation and Linearisation of Active Tension in Strongly Coupled Cardiac Electro-Mechanics Simulations},
	journal = {Computer Methods in Biomechanics and Biomedical Engineering},
	volume = {17},
	number = {6},
	year = {2014},
	pages = {604-15},
	publisher = { },
	abstract = {Mathematical models of cardiac electro-mechanics typically consist of three tightly coupled parts: systems of ordinary differential equations describing electro-chemical reactions and cross-bridge dynamics in the muscle cells, a system of partial differential equations modelling the propagation of the electrical activation through the tissue and a nonlinear elasticity problem describing the mechanical deformations of the heart muscle. The complexity of the mathematical model motivates numerical methods based on operator splitting, but simple explicit splitting schemes have been shown to give severe stability problems for realistic models of cardiac electro-mechanical coupling. The stability may be improved by adopting semi-implicit schemes, but these give rise to challenges in updating and linearising the active tension. In this paper we present an operator splitting framework for strongly coupled electro-mechanical simulations and discuss alternative strategies for updating and linearising the active stress component. Numerical experiments demonstrate considerable performance increases from an update method based on a generalised Rush-Larsen scheme and a consistent linearisation of active stress based on the first elasticity tensor.},
	author = {Sundnes, Joakim and Wall, Samuel and Osnes, Harald and Thorvaldsen, Tom and Andrew D. {McCulloch}}
}
