@article {25513,
	title = {Contributions of prestrains, hyperelasticity, and muscle fiber activation on mitral valve systolic performance},
	journal = { International Journal for Numerical Methods in Biomedical Engineering},
	volume = {33},
	number = {4},
	year = {2017},
	publisher = {John Wiley \& Sons},
	abstract = {The present study addresses the contributions of prestrains and muscle fiber activation to the global response of the mitral valve during systole. A finite element model of a porcine mitral valve is created using anatomical measurements and 3D echocardiographic recordings. The passive behavior of the leaflets is modeled using a transversely isotropic hyperelastic constitutive model, and we assume orthotropic muscle activations in the anterior leaflet. A simple approach to incorporate prestrains in the mitral valve apparatus is used by expanding the mitral annulus before applying the ventricular pressure to the mitral leaflets. Several finite element analyses are run with or without muscle activation and with or without prestrains. The analysis results are compared at peak systole with the echocardiograpic recordings. The case where prestrains and activation are accounted for simultaneously is the most efficient to approach the physiological flat shape of the closed valve observed in the echocardiograpic measurements. These results suggest that the active components present in the mitral leaflets and the presence of prestrains contribute to the physiological deformations of the mitral valve at peak systole and that material models based on\&nbsp;in vitro\&nbsp;mechanical testing are not sufficient for numerical studies of the mitral apparatus.\&nbsp;},
	author = {Victorien Emile {Prot} and Bj{\o}rn H. {Skallerud}}
}
