@phdthesis {28433,
	title = {Computing Microscopic Structure-Function Relationships in Contraction of the Heart},
	volume = {PhD},
	year = {2021},
	month = {11/2021},
	pages = {162},
	type = {Collection of Articles},
	abstract = {The micro-anatomical structures within cardiac muscle\&nbsp;cells are specialized to produce force rapidly and reliably.\&nbsp;Especially important are nanoscopic domains in the cell\&nbsp;named dyads, which are crucial for coupling electrical excitation of the cell and its contraction. With disease, these dyads\&nbsp;become disrupted and broken down, leading to a weaker contraction. However, due to their incredibly small size, it has been hard to\&nbsp;quantify how structures change and how changed anatomical architecture\&nbsp;affects function. Computational modeling and analysis therefore plays a\&nbsp;critical role in furthering our understanding of structure-function relationships\&nbsp;in cardiac cells.In this work, we present new tools and techniques for imaging and analyzing\&nbsp;cardiac dyads using super-resolution microscopy. This allows for better\&nbsp;quantification of how dyads change with disease. Based on microscopy\&nbsp;data we also generate computational geometries which we combine\&nbsp;with mathematical reaction-diffusion\&nbsp; modeling to yield new insight into\&nbsp;structure-function relationships in contraction of the heart.},
	isbn = {15017710},
	author = {van den Brink, Jonas}
}
