@article {sundnes2023computational,
	title = {Editorial: Computational models of cardiovascular growth and remodeling},
	journal = {Frontiers in Physiology},
	volume = {14},
	year = {2023},
	pages = {56},
	publisher = {Frontiers},
	doi = { https://doi.org/10.3389/fphys.2023.1130420},
	url = {https://www.frontiersin.org/articles/10.3389/fphys.2023.1130420/full},
	author = {Sundnes, Joakim and Lik Chuan {Lee} and Wall, Samuel and Valdez-Jasso, Daniela}
}
@misc {odeigah2022computational,
	title = {A computational model of right ventricular remodelling in the presence of pulmonary arterial hypertension},
	howpublished = {Biophysical Journal},
	year = {2022},
	month = {02/2022},
	publisher = {Elsevier},
	address = {Biophysical Society Annual Meeting, San Francisco, California, USA},
	abstract = {During early-stage pulmonary arterial hypertension (PAH), the right ventricle (RV) undergoes anatomical adaptation in the form of a thickened RV free wall, and material adaptation in the form of altered passive stiffness and contractility. The early-stage compensatory adaptations may help to preserve cardiac output but can later evolve into maladaptive remodelling and organ failure. The transition from compensatory to detrimental remodelling remains poorly understood.Using\&nbsp;in vivo\&nbsp;hemodynamic and morphological data from normotensive and hypertensive rats, we built idealized bi-ventricular finite element models representing different disease stages. We built a total of eight models, with RV wall thickness based on\&nbsp;ex vivo\&nbsp;measurements and passive material properties prescribed based on planar biaxial mechanical data obtained from the same animals. A previously developed inverse finite element framework was then used to fit the biventricular models to the\&nbsp;in-vivo\&nbsp;hemodynamic data, resulting in passive stiffness and contractility optimized to provide the best possible fit with the combined hemodynamic and biaxial data.Model simulations were then used to study how the presence of PAH affects the stress distribution in the right ventricular free wall, and how wall stress and RV function are altered by the induced changes in morphology, passive stiffness and contractility. Further numerical experiments were conducted to gain insight into the relative contribution of geometric and material adaptation to maintaining RV function in early-stage PAH, as well as the role of the septal wall. Such insights can facilitate a more comprehensive understanding of the compensatory remodeling that occurs during the disease progression.},
	author = {Odeigah, Oscar and Sundnes, Joakim and Bennington, Michael and Valdez-Jasso, Daniela}
}
@article {odeigah2022computational,
	title = {Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload},
	journal = {Frontiers in Physiology},
	year = {2022},
	pages = {1774},
	publisher = {Frontiers},
	abstract = {Pulmonary arterial hypertension (PAH) is associated with substantial remodeling of the right ventricle (RV), which may at first be compensatory but at a later stage becomes detrimental to RV function and patient survival. Unlike the left ventricle (LV), the RV remains understudied, and with its thin-walled crescent shape, it is often modeled simply as an appendage of the LV. Furthermore, PAH diagnosis is challenging because it often leaves the LV and systemic circulation largely unaffected. Several treatment strategies such as atrial septostomy, right ventricular assist devices (RVADs) or RV resynchronization therapy have been shown to improve RV function and the quality of life in patients with PAH. However, evidence of their long-term efficacy is limited and lung transplantation is still the most effective and curative treatment option. As such, the clinical need for improved diagnosis and treatment of PAH drives a strong need for increased understanding of drivers and mechanisms of RV growth and remodeling (G\&amp;R), and more generally for targeted research into RV mechanics pathology. Computational models stand out as a valuable supplement to experimental research, offering detailed analysis of the drivers and consequences of G\&amp;R, as well as a virtual test bench for exploring and refining hypotheses of growth mechanisms. In this review we summarize the current efforts towards understanding RV G\&amp;R processes using computational approaches such as reduced-order models, three dimensional (3D) finite element (FE) models, and G\&amp;R models. In addition to an overview of the relevant literature of RV computational models, we discuss how the models have contributed to increased scientific understanding and to potential clinical treatment of PAH patients.},
	author = {Oscar O {Odeigah} and Valdez-Jasso, Daniela and Wall, Samuel and Sundnes, Joakim}
}
