@article {Lee20143115,
	title = {Bioinjection treatment: Effects of post-injection residual stress on left ventricular wall stress},
	journal = {Journal of Biomechanics},
	volume = {47},
	year = {2014},
	pages = {3115 - 3119},
	publisher = {Elsevier},
	abstract = {Injection of biomaterials into diseased myocardium has been associated with decreased myofiber stress, restored left ventricular (LV) geometry and improved \{LV\} function. However, its exact mechanism(s) of action remained unclear. In this work, we present the first patient-specific computational model of biomaterial injection that accounts for the possibility of residual strain and stress introduced by this treatment. We show that the presence of residual stress can create more heterogeneous regional myofiber stress and strain fields. Our simulation results show that the treatment generates low stress and stretch areas between injection sites, and high stress and stretch areas between the injections and both the endocardium and epicardium. Globally, these local changes are translated into an increase in average myofiber stress and its standard deviation (from 6.9{\textpm}4.6 to 11.2{\textpm}48.8 kPa and 30{\textpm}15 to 35.1{\textpm}50.9 kPa at end-diastole and end-systole, respectively). We also show that the myofiber stress field is sensitive to the void-to-size ratio. For a constant void size, the myofiber stress field became less heterogeneous with decreasing injection volume. These results suggest that the residual stress and strain possibly generated by biomaterial injection treatment can have large effects on the regional myocardial stress and strain fields, which may be important in the remodeling process.},
	doi = {http://dx.doi.org/10.1016/j.jbiomech.2014.06.026},
	url = {http://www.sciencedirect.com/science/article/pii/S0021929014003650},
	author = {Lik Chuan {Lee} and Wall, Samuel and Genet, Martin and Hinson, Andy and Julius M. {Guccione}}
}
@article {Simula.simula.2238,
	title = {Algisyl-LVR With Coronary Artery Bypass Grafting Reduces Left Ventricular Wall Stress and Improves Function in the Failing Human Heart},
	journal = {International Journal of Cardiology},
	volume = {168},
	number = {3},
	year = {2013},
	month = {October},
	pages = {2022-2028},
	keywords = {Workshop},
	author = {Lik Chuan {Lee} and Wall, Samuel and Klepach, Doron and Ge, Liang and Zhang, Zhihong and Lee, Randall and Hinson, Andy and Joseph H. {Gorman} and Gorman, Robert and Guccione, Julius}
}
