@article {ALBATAT2021104159,
	title = {Optimal pacing sites in cardiac resynchronization by left ventricular activation front analysis},
	journal = {Computers in Biology and Medicine},
	volume = {128},
	year = {2021},
	pages = {104159},
	publisher = {Elsevier},
	abstract = {Cardiac resynchronization therapy (CRT) can substantially improve dyssynchronous heart failure and reduce mortality. However, about one-third of patients who are implanted, derive no measurable benefit from CRT. Non-response may partly be due to suboptimal activation of the left ventricle (LV) caused by electrophysiological heterogeneities. The goal of this study is to investigate the performance of a newly developed method used to analyze electrical wavefront propagation in a heart model including myocardial scar and compare this to clinical benchmark studies. We used computational models to measure the maximum activation front (MAF) in the LV during different pacing scenarios. Different heart geometries and scars were created based on cardiac MR images of three patients. The right ventricle (RV) was paced from the apex and the LV was paced from 12 different sites, single site, dual-site and triple site. Our results showed that for single LV site pacing, the pacing site with the largest MAF corresponded with the latest activated regions of the LV demonstrated during RV pacing, which also agrees with previous markers used for predicting optimal single-site pacing location. We then demonstrated the utility of MAF in predicting optimal electrode placements in more complex scenarios including scar and multi-site LV pacing. This study demonstrates the potential value of computational simulations in understanding and planning CRT.},
	keywords = {Cardiac resynchronization therapy, Cardiology, Computational modeling, electrophysiology, Heart failure},
	issn = {0010-4825},
	doi = {https://doi.org/10.1016/j.compbiomed.2020.104159},
	url = {http://www.sciencedirect.com/science/article/pii/S001048252030490X},
	author = {Albatat, Mohammad and Arevalo, Hermenegild and Bergsland, Jacob and Str{\o}m, Vilde and Balasingham, Ilangko and Hans Henrik {Odland}}
}
@article {27666,
	title = {Regional Left Ventricular Fiber Stress Analysis for Cardiac Resynchronization Therapy Response},
	journal = {Journal of Cardiovascular Electrophysiology},
	year = {2020},
	publisher = { Wiley},
	author = {Albatat, Mohammad and Finsberg, Henrik and Arevalo, Hermenegild and Sundnes, Joakim and Bergsland, Jacob and Balasingham, Ilangko and Hans Henrik {Odland}}
}
@article {27156,
	title = {Technological and Clinical Challenges in Lead Placement for Cardiac Rhythm Management Devices},
	journal = {Annals of Biomedical Engineering},
	volume = {48},
	year = {2020},
	month = {01/2020},
	pages = {26 - 46},
	publisher = {Springer Link},
	issn = {0090-6964},
	doi = {10.1007/s10439-019-02376-0},
	author = {Albatat, Mohammad and Bergsland, Jacob and Arevalo, Hermenegild and Hans Henrik {Oddland} and Bose, Pritam and Per Steinar {Halvorsen} and Balasingham, Ilangko}
}
@inproceedings {26370,
	title = {Electromechanical Model to Predict Cardiac Resynchronization Therapy},
	journal = {2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
	year = {2018},
	pages = {5446-5459},
	publisher = {IEEE},
	doi = {10.1109/EMBC.2018.8513539},
	author = {Albatat, Mohammad and King, Ryan and Unger, Laura and Arevalo, Hermenegild and Wall, Samuel and Sundnes, Joakim and Bergsland, Jacob and Balasingham, Ilangko}
}
