@article {23371,
	title = {A computational pipeline for quantification of mouse myocardial stiffness parameters},
	journal = {Computers in Biology and Medicine},
	volume = {53},
	year = {2014},
	pages = {65{\textendash}75},
	publisher = {Comput. Biol. Med.},
	abstract = {The mouse is an important model for theoretical-experimental cardiac research, and biophysically based whole organ models of the mouse heart are now within reach. However, the passive material properties of mouse myocardium have not been much studied. We present an experimental setup and associated computational pipeline to quantify these stiffness properties. A mouse heart was excised and the left ventricle experimentally inflated from 0 to 1.44kPa in eleven steps, and the resulting deformation was estimated by echocardiography and speckle tracking. An in silico counterpart to this experiment was built using finite element methods and data on ventricular tissue microstructure from diffusion tensor {MRI}. This model assumed a hyperelastic, transversely isotropic material law to describe the force-deformation relationship, and was simulated for many parameter scenarios, covering the relevant range of parameter space. To identify well-fitting parameter scenarios, we compared experimental and simulated outcomes across the whole range of pressures, based partly on gross phenotypes (volume, elastic energy, and short- and long-axis diameter), and partly on node positions in the geometrical mesh. This identified a narrow region of experimentally compatible values of the material parameters. Estimation turned out to be more precise when based on changes in gross phenotypes, compared to the prevailing practice of using displacements of the material points. We conclude that the presented experimental setup and computational pipeline is a viable method that deserves wider application.},
	issn = {1879-0534},
	doi = {10.1016/j.compbiomed.2014.07.013},
	author = {Nordb{\o}, Oyvind and Lamata, Pablo and Land, Sander and Steven A {Niederer} and Jan M. {Aronsen} and William E. {Louch} and Sjaastad, Ivar and Martens, Harald and Arne B. {Gjuvsland} and T{\o}ndel, Kristin and Torp, Hans and Lohezic, Maelene and Jurgen E. {Schneider} and Espen W. {Remme} and Nicolas P. {Smith} and Stig W. {Omholt}}
}
@inbook {Simula.simula.2686,
	title = {PLS-Based Multivariate Metamodeling of Dynamic Systems},
	booktitle = {New Perspectives in Partial Least Squares and Related Methods},
	volume = {56},
	year = {2013},
	pages = {3-30},
	publisher = {Springer},
	organization = {Springer},
	chapter = {1},
	address = {New York},
	author = {Martens, Harald and T{\o}ndel, Kristin and Tafintseva, Valeriya and Kohler, Achim and Plathe, Erik and Jon Olav {Vik} and Arne B. {Gjuvsland} and Stig W. {Omholt}},
	editor = {Abdi, H. and W. W. {Chin} and V. E. {Vinzi} and Russolillo, G. and Trinchera, L.}
}
@article {karticlereference.2014-04-03.9225258604,
	title = {Multi-Way Metamodelling Facilitates Insight Into the Complex Input-Output Maps of Nonlinear Dynamic Models},
	journal = {BMC Systems Biology},
	volume = {6},
	number = {1},
	year = {2012},
	pages = {88},
	publisher = {BioMedCentral},
	author = {T{\o}ndel, Kristin and Ulf G. {Indahl} and Arne B. {Gjuvsland} and Stig W. {Omholt} and Martens, Harald}
}
@article {Simula.simula.2680,
	title = {Genotype-Phenotype Map Characteristics of an in Silico Heart Cell},
	journal = {Frontiers in Physiology},
	volume = {2},
	number = {1},
	year = {2011},
	pages = {106},
	publisher = {NCBI},
	author = {Jon Olav {Vik} and Arne B. {Gjuvsland} and Li, Liren and T{\o}ndel, Kristin and Steven A {Niederer} and Nicolas P. {Smith} and Peter J. {Hunter} and Stig W. {Omholt}}
}
@article {Simula.simula.2682,
	title = {Hierarchical Cluster-Based Partial Least Squares Regression Is an Efficient Tool for Metamodelling of Nonlinear Dynamic Models},
	journal = {BMC Systems Biology},
	volume = {5},
	number = {1},
	year = {2011},
	pages = {90},
	publisher = {BioMedCentral},
	doi = {10.1186/1752-0509-5-90},
	author = {T{\o}ndel, Kristin and Ulf G. {Indahl} and Arne B. {Gjuvsland} and Jon Olav {Vik} and Peter J. {Hunter} and Stig W. {Omholt} and Martens, Harald}
}
@article {Simula.simula.2678,
	title = {Screening Design for Computer Experiments: Metamodelling of a Deterministic Mathematical Model of the Mammalian Circadian Clock},
	journal = {Journal of Chemometrics},
	volume = {24},
	number = {1},
	year = {2010},
	pages = {738-747},
	publisher = {John Wiley \& Sons},
	author = {T{\o}ndel, Kristin and Arne B. {Gjuvsland} and M{\r a}ge, Ingrid and Martens, Harald}
}
