@article {43168,
	title = {Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space {\textendash} a computational study},
	journal = {PLoS Computational Biology},
	volume = {19},
	year = {2023},
	month = {07/2023},
	pages = {e1010996},
	publisher = {Public Library of Science},
	doi = {https://doi.org/10.1371/journal.pcbi.1010996},
	url = {https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010996},
	author = {Marte J. {S{\ae}tra} and Ada Johanne {Ellingsrud} and Marie E. {Rognes}}
}
@misc {42926,
	title = {Computational brainphatics: coupled models of mechanics and electrophysiology in brain tissue},
	howpublished = {DigiBrain Symposium, Simula Research Laboratory, Oslo, Norway},
	year = {2022},
	author = {Ada Johanne {Ellingsrud} and Marie E. {Rognes}}
}
@misc {42929,
	title = {Finite element simulation of ionic electrodiffusion in cellular geometries},
	howpublished = {University of Pennsylvania, Philadelphia, USA},
	year = {2022},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {42931,
	title = {Finite element simulation of ionic electrodiffusion in cellular geometries},
	howpublished = {CAIMS/SCMAI 2022, Kelowna, Canada},
	year = {2022},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {42855,
	title = {Modeling electrodiffusive, osmotic, and hydrostatic interplay in astrocyte networks},
	year = {2022},
	month = {11/2022},
	publisher = {Society for Neuroscience},
	address = {Neuroscience 2022},
	abstract = {During high neuronal activity, the intra- and extracellular ion concentrations change. These changes affect the osmotic pressure gradients across the membranes of both neurons and astrocytes, leading to water movement and cellular swelling. We asked: Can swelling generate a hydrostatic pressure gradient of sufficient magnitude to drive non-negligible fluid flow within astrocytes or the extracellular space [1]? As it is currently infeasible to measure such intracellular pressure gradients in vivo, computational modeling emerges as a viable alternative to study the interplay between osmotic and hydrostatic forces at the microscale.\&nbsp;\&nbsp;In this study, we present a computational model of ionic electrodiffusion, hydrostatic pressures, and transmembrane- and intracompartmental fluid flow in a homogenized astrocytic syncytium surrounded by extracellular space. The model builds on previous models of ionic electrodiffusion [2,3],\&nbsp;and potassium buffering [4]. Our findings show that increases in extracellular potassium concentrations in response to neuronal activity induce swelling and hydrostatic pressure gradients within the intra- and extracellular spaces. The fluid flow induced by these hydrostatic pressure gradients alone did not have a significant effect on the transport of potassium within any of the compartments. However, when also accounting for fluid flow induced by osmotic gradients within the astrocytic syncytium, convection played a considerable role in potassium clearance. These findings point at a mechanistic understanding of how astrocytic permeability may impact fluid flow in the brain.[1] Halnes, G., Pettersen, K. H., {\O}yehaug, L., Rognes, M. E. \&amp; Einevoll, G. T. Astrocytic ion dynamics: Implications for potassium buffering and liquid flow. In Computational Glioscience, 363{\textendash}391 (Springer, 2019).[2] Mori, Y. A multidomain model for ionic electrodiffusion and osmosis with an application to cortical spreading depression. Phys. D: Nonlinear Phenom. 308, 94{\textendash}108 (2015).[3]\&nbsp; Zhu, Y., Xu, S., Eisenberg, R. S. \&amp; Huang, H. Optic nerve microcirculation: Fluid flow and electrodiffusion. Phys. Fluids 33, 041906 (2021).[4] Halnes, G., {\O}stby, I., Pettersen, K. H., Omholt, S. W. \&amp; Einevoll, G. T. Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. PLoS computational biology 9, e1003386 (2013).},
	author = {Marte J. {S{\ae}tra} and Ada Johanne {Ellingsrud} and Marie E. {Rognes}}
}
@misc {42930,
	title = {Numerical simulation of electrodiffusion and osmosis in brain tissue},
	howpublished = {9th World Congress of Biomechanics, online},
	year = {2022},
	author = {Ada Johanne {Ellingsrud}}
}
@article {ellingsrud2021validating,
	title = {Validating a computational framework for ionic electrodiffusion with cortical spreading depression as a case study},
	journal = {eNeuro},
	volume = {9},
	number = {2},
	year = {2022},
	month = {04/2022},
	publisher = {Society for Neuroscience},
	author = {Ada Johanne {Ellingsrud} and Didrik B. {Dukefoss} and Enger, Rune and Halnes, Geir and Pettersen, Klas and Marie E. {Rognes}}
}
@article {paper31,
	title = {Abstractions and automated algorithms for mixed-dimensional finite element methods},
	journal = {ACM Transactions on Mathematical Software},
	volume = {47},
	year = {2021},
	month = {09/2021},
	pages = {1-36},
	publisher = {ACM},
	author = {Daversin-Catty, C{\'e}cile and Chris N. {Richardson} and Ada Johanne {Ellingsrud} and Marie E. {Rognes}}
}
@misc {28263,
	title = {Accurate numerical simulation of electrodiffusion and water movement in brain tissue with cortical spreading depression as a case study},
	howpublished = {Interpore 13th annual meeting (online)},
	year = {2021},
	type = {Conference talk},
	address = {Online},
	author = {Ada Johanne {Ellingsrud} and Marie E. {Rognes}},
	editor = {Farrell, Patrick and Boull{\'e}, Nicolas and Didrik B. {Dukefoss} and Enger, Rune and Pettersen, Klas and Halnes, Geir}
}
@article {paper36,
	title = {Accurate numerical simulation of electrodiffusion and water movement in brain tissue},
	journal = {IMA Mathematical Medicine and Biology},
	volume = {38},
	year = {2021},
	month = {11/2021},
	pages = {516{\textendash}551},
	publisher = {IMA},
	author = {Ada Johanne {Ellingsrud} and Boull{\'e}, Nicolas and Patrick E. {Farrell} and Marie E. {Rognes}}
}
@inbook {27254,
	title = {A cell-based model for ionic electrodiffusion in excitable tissue},
	booktitle = {Modeling Excitable Tissue: The EMI Framework},
	number = {7},
	year = {2021},
	pages = {14-27},
	publisher = {Springer International Publishing},
	organization = {Springer International Publishing},
	address = {Cham},
	url = {https://www.springer.com/gp/book/9783030611569},
	author = {Ada Johanne {Ellingsrud} and Daversin-Catty, C{\'e}cile and Marie E. {Rognes}},
	editor = {Mardal, Kent-Andre and Marie E. {Rognes} and Tveito, Aslak}
}
@phdthesis {28403,
	title = {Computational modelling of electrodiffusion and osmosis in cerebral tissue},
	volume = {PhD},
	year = {2021},
	author = {Ada Johanne {Ellingsrud}}
}
@article {paper30,
	title = {Finite element simulation of ionic electrodiffusion in cellular geometries},
	journal = {Frontiers in Neuroinformatics},
	volume = {14},
	year = {2020},
	pages = {11},
	publisher = {Frontiers},
	doi = {https://doi.org/10.3389/fninf.2020.00011},
	author = {Ada Johanne {Ellingsrud} and Solbraa, Andreas and Gaute T. {Einevoll} and Halnes, Geir and Marie E. {Rognes}}
}
@misc {28264,
	title = {Finite element simulation of ionic electrodiffusion in cellular geometries},
	howpublished = {Online},
	year = {2020},
	publisher = {29th annual computational neuroscience meeting},
	type = {Conference talk},
	address = {Online},
	author = {Ada Johanne {Ellingsrud} and Marie E. {Rognes}},
	editor = {Halnes, Geir and Solbr{\r a}, Andreas and Einevoll, Gaute}
}
@inproceedings {28265,
	title = {Parametric exploration of cellular swelling in a computational model of cortical spreading depression},
	journal = {2020 42nd Annual International Conference of the IEEE Engineering in Medicine \&amp; Biology Society (EMBC)},
	year = {2020},
	month = {07/2020},
	pages = {2491-2495},
	publisher = {IEEE},
	address = {Montreal, QC, Canada},
	author = {Genocchi, Barbara and Cunha, Andr{\'e} and Jain, Soumil and Hyttinen, Jari and Lenk, Kerstin and Ada Johanne {Ellingsrud}}
}
@misc {27018,
	title = {A computational model for cerebral electrodiffusion based on explicit geometrical representation},
	howpublished = {FEniCS 2019, Washington DC, USA},
	year = {2019},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {27019,
	title = {A mathematical framework for cerebral electrodiffusion based on explicit geometrical representation},
	howpublished = {Workshop with UiB, Oslo, Norway},
	year = {2019},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {27017,
	title = {Mathematical modelling of glials - the forgotten brain cell},
	year = {2019},
	publisher = {The "Ada Lovlace day" arranged by EL\&IT (Oslo, Norway)},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {27020,
	title = {Modelling of the role of glial cells in cerebral interstitial fluid movement},
	year = {2018},
	address = {FEniCS 2018 (Oxford, UK)},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {27016,
	title = {Modelling of the role of glial cells in cerebral interstitial fluid movement},
	year = {2018},
	address = {IMA workshop on Mathematical Modeling of Cortical Spreading Depression and Related Phenomena (Minneapolis, USA)},
	author = {Ada Johanne {Ellingsrud}}
}
@misc {25820,
	title = {Modelling of the role of glial cells in cerebral interstitial fluid movement},
	year = {2017},
	address = { 5th HBP School on Future Medicine, Obergurgl, Austria},
	author = {Ada Johanne {Ellingsrud}}
}
