@misc {26550,
	title = {Are High-Frequency Aneurysm Wall Vibrations of Importance?},
	howpublished = {6th International Conference on Computational and Mathematical Biomedical Engineering {\textendash} CMBE2019, Sendai, Japan },
	year = {2019},
	abstract = {We present a preliminary study on aneurysm wall vibrations associated with turbulent-like hemodynamics in intracranial vascular sections. The specificity of our numerical model is to explore the fluid/structure coupling of the arterial flow and the wall mechanics to relatively high frequencies (100-500 Hz). Despite the computational cost of the couple FSI problem and its direct impact on the resolutions of the model presented here, our findings highlight an important mechanical interplay resulting in a complex, but characteristic, deformation of the arterial wall. We hope to stimulate discussions and further work towards this physiological process, which can potentially have important implications for cell signaling mechanisms.},
	keywords = {fluid-structure interaction, Intracranial aneurysm, wall vibrations},
	author = {Souche, Alban and Valen-Sendstad, Kristian}
}
@article {26192,
	title = {Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge},
	journal = {Cardiovascular Engineering and Technology},
	volume = {9},
	year = {2018},
	month = {10/2018},
	pages = {544{\textendash}564},
	publisher = {Springer},
	address = {US},
	abstract = {PurposeImage-based computational fluid dynamics (CFD) is widely used to predict intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture risk assessment. Nevertheless, concern has been expressed over the variability of predicted WSS and inconsistent associations with rupture. Previous challenges, and studies from individual\&nbsp;groups,\&nbsp;have focused on individual aspects of the image-based CFD pipeline. The aim of this Challenge was to quantify the total variability of the whole pipeline.Methods3D rotational angiography image volumes of five middle cerebral artery aneurysms were provided to participants, who were free to choose their segmentation methods, boundary conditions, and CFD solver and settings. Participants were asked to fill out a questionnaire about their solution strategies and experience with aneurysm CFD, and provide surface distributions of WSS magnitude, from which we objectively derived a variety of hemodynamic parameters.ResultsA total of 28 datasets were submitted, from 26 teams with varying levels of self-assessed experience.\&nbsp;Wide\&nbsp;variability of segmentations, CFD model extents, and inflow rates resulted in interquartile ranges of sac average WSS up to 56\%, which reduced to \&lt; 30\% after normalizing by parent artery WSS. Sac-maximum WSS and low shear area were more variable, while rank-ordering of cases by low or high shear showed\&nbsp;only\&nbsp;modest consensus among teams.\&nbsp;Experience\&nbsp;was not a significant predictor of variability.ConclusionsWide variability exists in the prediction of intracranial aneurysm WSS. While segmentation and CFD solver techniques may be difficult to standardize across groups, our findings suggest that some of the variability in image-based CFD could be reduced by establishing guidelines for model extents, inflow rates, and blood properties, and by encouraging the reporting of normalized hemodynamic parameters.},
	keywords = {Intracranial aneurysm, Patient-specific modeling, Rupture risk, Uncertainty quantification, Wall shear stress},
	issn = {1869-408X},
	doi = {10.1007/s13239-018-00374-2},
	url = {https://goo.gl/mG9u9t},
	author = {Valen-Sendstad, Kristian and Bergersen, Aslak and Shimogonya, Yuji and Goubergrits, Leonid and Bruening, Jan and Pallares, Jordi and Cito, Salvatore and Piskin, Senol and Pekkan, Kerem and Arjan J. {Geers} and Larrabide, Ignacio and Rapaka, Saikiran and Mihalef, Viorel and Fu, Wenyu and Qiao, Aike and Jain, Kartik and Roller, Sabine and Mardal, Kent-Andre and Kamakoti, Ramji and Spirka, Thomas and Ashton, Neil and Revell, Alistair and Aristokleous, Nicolas and Houston, Graeme and Tsuji, Masanori and Ishida, Fujimaro and Prahlad G. {Menon} and Leonard D. {Browne} and Broderick, Stephen and Shojima, Masaaki and Koizumi, Satoshi and Barbour, Michael and Aliseda, Alberto and Hern{\'a}n G. {Morales} and Lef{\`e}vre, Thierry and Hodis, Simona and Yahia M. {Al-Smadi} and Justin S. {Tran} and Alison L. {Marsden} and Vaippummadhom, Sreeja and Einstein, Albert and Alistair G. {Brown} and Debus, Kristian and Niizuma, Kuniyasu and Rashad, Sherif and Sugiyama, Shin-ichiro and Owais Mohammad {Khan} and Adam R. {Updegrove} and Shawn C. {Shadden} and Bart M. W. {Cornelissen} and Charles B. L. M. {Majoie} and Ber, Philipp and Saalfield, Sylvia and Kono, Kenichi and David A. {Steinmam}}
}
