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2020
J. Dhamala, P. Bajracharya, H. Arevalo, J. L. Sapp, M. B. Horácek, K. C. Wu, N. A. Trayanova and L. Wang. "Embedding high-dimensional Bayesian optimization via generative modeling: Parameter personalization of cardiac electrophysiological models." Medical Image Analysis 62 (2020): 101670.
F. Vadakkumpadan, H. Arevalo, N. A. Trayanova and K. Wu. System and method for personalized cardiac arrhythmia risk assessment by simulating arrhythmia inducibility., 2020.
2018
D. Deng, P. P. Nikolov, H. Arevalo and N. A. Trayanova. "Optimal contrast-enhanced MRI image thresholding for accurate prediction of ventricular tachycardia using ex-vivo high resolution models." Computers in biology and medicine 102 (2018): 426-432.
J. Dhamala, H. Arevalo, J. Sapp, M. B. Horácek, K. C. Wu, N. A. Trayanova and L. Wang. "Quantifying the uncertainty in model parameters using Gaussian process-based Markov chain Monte Carlo in cardiac electrophysiology." Medical Image Analysis 48 (2018): 43-57.
2016
H. Arevalo, F. Vadakkumpadan, E. Guallar, A. Jebb, P. Malamas, K. C. Wu and N. A. Trayanova. "Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models." Nature Communications 7 (2016).
H. Arevalo, P. M. Boyle and N. A. Trayanova. "Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia." Progress in Biophysics and Molecular Biology 121, no. 2 (2016): 185-194.
T. Bruegmann, P. M. Boyle, C. Vogt, T. Karathanos, H. Arevalo, B. Fleishmann, N. A. Trayanova and P. Sasse. "Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations." The Journal of Clnical Investigation 126, no. 10 (2016).
2015
D. Deng, H. Arevalo, F. Pashakhanloo, A. Prakosa, H. Ashikaga, E. McVeigh, H. Halperin and N. A. Trayanova. "Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI." Frontiers in Physiology 6, no. 282 (2015).
E. Ukwatta, H. Arevalo, M. Rajchl, J. White, F. Pashakhanloo, A. Prakosa, D. A. Herzka, E. McVeigh, A. C. Lardo and N. A. Trayanova. "Image-based reconstruction of three-dimensional myocardial infarct geometry for patient-specific modeling of cardiac electrophysiology." Medical Physics 42, no. 8 (2015): 4579-90.
E. Ukwatta, H. Arevalo, K. Li, J. Yuan, W. Qiu, P. Malamas, K. C. Wu, N. A. Trayanova and F. Vadakkumpadan. "Myocardial Infarct Segmentation from Magnetic Resonance Images for Personalized Modeling of Cardiac Electrophysiology." IEEE Transactions on Medical Imaaging (2015).
S. Land, S. Arens, C. M. Augustin, L. Baron, S. Castro, A. Crozier, M. Favino, T. E. Fastl, T. Fritz, H. Gao et al. "Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour." Proceedings of the Royal Society A 471 (2015).
2014
A. Prakosa, P. Malamas, S. Zhang, F. Pashakhanloo, H. Arevalo, D. Herzka, A. Lardo, H. Halperin, E. McVeigh and N. A. Trayanova. "Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology." Progress in Biophysics and Molecular Biology 115 (2014): 226-34.
P. M. Boyle, C. J. Park, H. Arevalo, E. J. Vigmond and N. A. Trayanova. "Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles." PLOS ONE (2014).
2013
H. Arevalo, G. Plank, P. Helm, H. Halperin and N. A. Trayanova. "Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models." PLOS ONE (2013).
2012
F. Vadakkumpadan, H. Arevalo, C. Ceritoglu, M. Miller and N. A. Trayanova. "Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology." IEEE Transactions on Medical Imaging 31, no. 5 (2012): 1051-1060.
L. J. Rantner, H. Arevalo, J. L. Constantino, I. R. Efimov, G. Plank and N. A. Trayanova. "Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: Altered virtual electrode polarizations and conduction delay in the peri-infarct zone." Journal of Physiology 590 (2012): 4537-51.
2011
K. McDowell, H. Arevalo, M. Maleckar and N. A. Trayanova. "Susceptibility to Reentry in the Infarcted Heart Depends on the Active Fibroblast Density." Biophysical Journal 110 (2011): 1307-15.
2010
K. McDowell, H. Arevalo, M. Maleckar and N. A. Trayanova. "Fibroblast-Myocote Coupling Induces Alterations in Potassium Currents That Trigger Regional Action Potensial During (APD) Prolongation in Infarcted Myocardium." Heart Rhythm 7 (2010): 163-164.
F. Vadakkumpadan, H. Arevalo, A. J. Prassl, J. Chen, F. Kickinger, P. Kohl, G. Plank and N. A. Trayanova. "Image-based models of cardiac structure in health and disease." Wiley Interdisciplinary Reviews: Systems Biology and Medicine (2010).
2009
K. McDowell, H. Arevalo, M. Maleckar, B. RC, P. G and N. A. Trayanova. Effects of Fibroblast-Myocyte Coupling in the Infarcted Rabbit Heart In Heart Rhythm. Vol. 6., 2009.
M. Maleckar, J. L. Greenstein, W. R. Giles and N. A. Trayanova. "Electrotonic Coupling Between Human Atrial Myocytes and Fibroblasts Alters Excitability and Repolarization." Biophysical Journal 97 (2009): 2179-2190.PDF icon Simula.SC.448.pdf (986.82 KB)
M. Maleckar, J. L. Greenstein, W. R. Giles and N. A. Trayanova. "K+ Current Changes Account for the Rate Dependence of the Action Potential in the Human Atrial Myocyte." American Journal of Physiology - Heart and Circulatory Physiology 297 (2009): 1398-1410.PDF icon Simula.SC.450.pdf (1.52 MB)
E. Vigmond, F. Vadakkumpadan, H. Arevalo, M. Deo, G. Plank and N. A. Trayanova. "Towards predictive modelling of the electrophysiology of the heart." Experimental Physiology (2009).
2008
M. Maleckar, J. L. Greenstein, W. R. Giles and N. A. Trayanova. Coupling of Human Atrial Myocytes and Myofibroblasts Can Lead to Conduction Disturbances In HRS Scientific Sessions 2008., 2008.
M. Maleckar, J. L. Greenstein, N. A. Trayanova and W. R. Giles. "Mathematical Simulations of Ligand-Gated and Specific Cell-Type Effects in the Human Atrium." Progress in Biophysics and Molecular Biology 98 (2008): 161-70.

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