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Most recent publications

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics 134, no. 7 (2023).
Journal Article
2023
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A. G. Edwards, J. van den Brink and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 362-375. 8th ed. Vol. 1. Elsevier, 2021.
Book Chapter
2021
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V. Timmermann and A. D. McCulloch

Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes

Frontiers in physiology 11 (2020): 1573.
Journal Article
2020
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K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Journal Article
2020
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News

18 June 2019
People

Viviane Timmermann successfully defended her PhD

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2023

Journal articles

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics 134, no. 7 (2023).
Status: Published
2022

Talks, contributed

L. Pankewitz, S. Govil, K. G. Hustad, J. C. Perry, S. Hedge, R. Tang, A. D. McCulloch and H. Arevalo

Development of a Biventricular Coordinate System with Representation of an Anatomically Detailed Base

In Tampere , 2022.
Status: Accepted
2021

Book chapters

A. G. Edwards, J. van den Brink and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 362-375. 8th ed. Vol. 1. Elsevier, 2021.
Status: Published
2020

Journal articles

K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Status: Published
V. Timmermann and A. D. McCulloch

Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes

Frontiers in physiology 11 (2020): 1573.
Status: Published

Talks, contributed

K. J. McCabe, Y. Aboelkassem, A. Teitgen, M. Regnier and A. D. McCulloch

Multiscale modelling determines mechanisms of action for 2'-deoxy-ATP, a myosin activating therapeutic for heart failure

In VPH 2020, Paris, France (Virtual). VPH 2020, 2020.
Status: Published
2019

Journal articles

Y. Aboelkassem, K. J. McCabe, G. Huber, M. Regnier, A. J. McCammon and A. D. McCulloch

A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics

Biophysical Journal 117, no. 12 (2019): 2255-2272.
Status: Published
Y. Aboelkassem, J. D. Powers, K. J. McCabe and A. D. McCulloch

Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies

Current Opinion in Biomedical Engineering 11 (2019): 35-44.
Status: Published
K. H. Jæger, A. G. Edwards, A. D. McCulloch and A. Tveito

Properties of cardiac conduction in a cell-based computational model

PLoS Computational Biology 15, no. 5 (2019).
Status: Published
J. D. Powers, C. Yuan, K. J. McCabe, J. D. Murray, M. C. Childers, G. V. Flint, F. Moussavi-Harami, S. Mohran, R. Castillo, C. Zuzek et al.

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

Proceedings of the National Academy of Sciences (2019).
Status: Published