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Most recent publications

V. Timmermann and A. D. McCulloch

Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes

Frontiers in physiology 11 (2020): 1573.
Journal Article
2020
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K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Journal Article
2020
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S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

The Journal of Physical Chemistry B 120, no. 33 (2016): 8264-8275.
Journal Article
2016
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A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch

Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states

Mathematical Biosciences 277 (2016): 126-135.
Journal Article
2016
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News

18 June 2019
People

Viviane Timmermann successfully defended her PhD

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Export 11 results:
2020

Journal articles

K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Status: Published
V. Timmermann and A. D. McCulloch

Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes

Frontiers in physiology 11 (2020): 1573.
Status: Published

Talks, contributed

K. J. McCabe, Y. Aboelkassem, A. Teitgen, M. Regnier and A. D. McCulloch

Multiscale modelling determines mechanisms of action for 2'-deoxy-ATP, a myosin activating therapeutic for heart failure

In VPH 2020, Paris, France (Virtual). VPH 2020, 2020.
Status: Published
2018

Posters

Y. Aboelkassem, K. J. McCabe, G. Huber, J. Sundnes and A. D. McCulloch

Turning the Azimuthal Motions of Adjacent Tropomyosins into a Coupled N-body Problem in a Brownian Model of Cardiac Thin Filament Activation

In Biophysical Journal. San Francisco, California/U.S.A.: Elsevier, 2018.
Status: Published
K. J. McCabe, Y. Aboelkassem, S. Dewan, M. Regnier and A. D. McCulloch

A Markov State Model of the Sarcomere to Explain the Effects of dATP on Cardiac Contraction

Biophysical Society 62nd Annual Meeting, San Francisco CA, 2018.
Status: Published

Talks, contributed

V. Timmermann, J. Sundnes, S. Wall, A. D. McCulloch and A. G. Edwards

A computational study of the contribution of mechano-electric feedback to arrhythmogenic current generation

In Berlin, Germany. Heart by Numbers, Biophysical Society, 2018.
Status: Published
2016

Journal articles

S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

The Journal of Physical Chemistry B 120, no. 33 (2016): 8264-8275.
Status: Published
S. Morotti, A. D. McCulloch, D. M. Bers, A. G. Edwards and E. Grandi

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Journal of Molecular and Cellular Cardiology 96 (2016): 63-71.
Status: Published
A. Tveito, G. T. Lines, A. G. Edwards and A. D. McCulloch

Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states

Mathematical Biosciences 277 (2016): 126-135.
Status: Published

Book chapters

A. G. Edwards, J. E. Hake, A. P. Michailova, M. Hoshijima and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries (7th Edition)

In Cardiac Electrophysiology: From Cell to Bedside. 7th ed. Elsevier Science, 2016.
Status: Accepted