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Most recent publications

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics 134, no. 7 (2023).
Journal Article
2023
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A. G. Edwards, J. van den Brink and A. D. McCulloch

Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

In Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 362-375. 8th ed. Vol. 1. Elsevier, 2021.
Book Chapter
2021
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V. Timmermann and A. D. McCulloch

Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes

Frontiers in physiology 11 (2020): 1573.
Journal Article
2020
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K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Journal Article
2020
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2012

Posters

A. G. Edwards, J. E. Hake, J. H. Brown and A. D. McCulloch

βAR-Stimulation Causes EADs But Not DADs in Pre-Failure CAMKIIδC Transgenic Myocytes

In Biophysical Society annual meeting, 2012.
Status: Published
J. E. Hake, A. G. Edwards, Z. Yu, P. M. Kekenes-Huskey, A. P. Michailova, A. J. McCammon, M. J. Holst, M. Hoshijima and A. D. McCulloch

Modeling Calcium Sparks in a Three-Dimensional Reconstruction of a Cardiac Calcium Release Unit

2012.
Status: Published
P. M. Kekenes-Huskey, J. E. Hake, Y. Cheng, M. J. Holst, F. B. Sachse, J. H. Bridge, A. D. McCulloch, A. J. McCammon and A. P. Michailova

Modeling Calcium Dynamics in Realistic Rabbit Ventricular Myocytes With Several Transverse Tubules

2012.
Status: Published
2011

Journal articles

S. G. Campbell and A. D. McCulloch

Multi-Scale Computational Models of Familial Hypertrophic Cardiomyopathy: Genotype to Phenotype

Journal of the Royal Society Interface 8, no. 64 (2011).
Status: Published
E. J. Howard, J. W. Covell, L. J. Mulligan, A. D. McCulloch and J. H. Omens

Improvement in Pump Function With Endocardial Biventricular Pacing Increases With Activation Time at the Left Ventricular Pacing Site in Failing Canine Hearts

American Journal of Physiology - Heart and Circulatory Physiology 301 (2011): H1447-H1455.
Status: Published
A. Tveito, G. T. Lines, P. Li and A. D. McCulloch

On Defining Candidate Drug Characteristics for Long-QT

Mathematical Biosciences and Engineering 8 (2011): 861-873.
Status: Published

Posters

J. E. Hake, W. E. Louch, K. Haugen, I. Sjaastad, O. M. Sejersted, A. D. McCulloch, A. P. Michailova and G. T. Lines

A Stochastic Model of the Ryanodine Receptor Featuring Coupled Gating and Competitive Binding of Luminal and Cytosolic Ca2+ and Mg2+

2011.
Status: Published
2010

Journal articles

S. G. Campbell, F. V. Lionetti, K. S. Campbell and A. D. McCulloch

Coupling of Adjacent Tropomyosins Enhances Cross-Bridge-Mediated Cooperative Activation in a Markov Model of the Cardiac Thin Filament

Biophysical Journal 98 (2010): 2254-2264.
Status: Published
Y. Cheng, Z. Yu, M. Hoshijima, M. J. Holst, A. D. McCulloch, A. J. McCammon and A. P. Michailova

Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes With Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum

PLoS Computational Biology 6 (2010): e1000972.
Status: Published
J. D. Feala, J. Cortes, P. M. Duxbury, C. Piermarocchi, A. D. McCulloch and G. Paternostro

Systems Approaches and Algorithms for Discovery of Combinatorial Therapies

Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2 (2010): 93.
Status: Published