In recent years, we have observed a rise of interest in the multimedia community towards research topics related to health. It can be observed that this goes into two interesting directions. One is personal health with a larger focus on well-being and everyday healthy living. The other direction focuses more on multimedia challenges within the health-care systems, for example, how can multimedia content produced in hospitals be used efficiently but also on the user perspective of patients and health-care personal. Challenges and requirements in this interesting and challenging direction are similar to classic multimedia research, but with some additional pitfalls and challenges. This tutorial aims to give a general introduction to the research area; to provide an overview of specific requirements, pitfalls and challenges; to discuss existing and possible future work; and to elaborate on how machine learning approaches can help in multimedia-related challenges to improve the health-care quality for patients and support medical experts in their daily work.