The history of the vertical motion of the Kalahari Plateau in South Africa during the Meso-Cenozoic is debated. Quantifying the terrigeneous sediment in the marine basins allows us to partially constrain the evolution of this continental relief in volumes and timing. In this study, we use data from 43 wells drilled in marginal basins in southern Mozambique, corrected for in situ sediment production as well as sediment compaction. The results we obtained show two periods of high accumulation rates. The first is recorded during Mid-Late Cretaceous and is recorded in similar studies of nearby margins in Namibia and South Africa. This evidence supports the hypothesis of a major uplift of the whole Kalahari Plateau in the Mid-Late Cretaceous. The second high accumulation rate is in the Miocene and is consistent with the hypothesis of a more localized relief reorganization driven by uplift of the eastern rim of the Kalahari Plateau feeding the Mozambique marginal basin.