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Most recent publications

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics 134, no. 7 (2023).
Journal Article
2023
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M. H. Mesa, J. van den Brink, W. E. Louch, K. J. McCabe and P. Rangamani

Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks

PLOS Computational Biology 18, no. 6 (2022): e1010126.
Journal Article
2022
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K. J. McCabe and P. Rangamani

Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes

Journal of Molecular and Cellular Cardiology 154 (2021): 32-40.
Journal Article
2021
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K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Journal Article
2020
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News

31 March 2023

New book in the SpringerBriefs series: Computational Physiology - Simula Summer School 2022 - Student Reports

Background

PhD, Bioengineering
University of California, San Diego
April 2019
MSc, Bioengineering
University of California, San Diego
December 2016
BSc, Biomedical Engineering
Yale University
May 2013

Awards

Engelson Ph.D. Thesis Award in Bioengineering
University of California, San Diego
June 2019
Siebel Scholar, Class of 2019
University of California, San Diego
August 2018

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Export 10 results:
2023

Journal articles

M. T. Hock, A. Teitgen, K. J. McCabe, S. P. Hirakis, G. Huber, M. Regnier, R. E. Amaro, A. J. McCammon and A. D. McCulloch

Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling

Journal of Applied Physics 134, no. 7 (2023).
Status: Published
2022

Journal articles

M. H. Mesa, J. van den Brink, W. E. Louch, K. J. McCabe and P. Rangamani

Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks

PLOS Computational Biology 18, no. 6 (2022): e1010126.
Status: Published
2021

Journal articles

K. J. McCabe and P. Rangamani

Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes

Journal of Molecular and Cellular Cardiology 154 (2021): 32-40.
Status: Published
2020

Journal articles

K. J. McCabe, Y. Aboelkassem, A. Teitgen, G. Huber, A. J. McCammon, M. Regnier and A. D. McCulloch

Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

Archives of Biochemistry and Biophysics 695 (2020): 108582.
Status: Published
2019

Journal articles

Y. Aboelkassem, K. J. McCabe, G. Huber, M. Regnier, A. J. McCammon and A. D. McCulloch

A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics

Biophysical Journal 117, no. 12 (2019): 2255-2272.
Status: Published
Y. Aboelkassem, J. D. Powers, K. J. McCabe and A. D. McCulloch

Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies

Current Opinion in Biomedical Engineering 11 (2019): 35-44.
Status: Published
J. D. Powers, C. Yuan, K. J. McCabe, J. D. Murray, M. C. Childers, G. V. Flint, F. Moussavi-Harami, S. Mohran, R. Castillo, C. Zuzek et al.

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

Proceedings of the National Academy of Sciences (2019).
Status: Published
2017

Journal articles

S. Dewan, K. J. McCabe, M. Regnier and A. D. McCulloch

Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype

Frontiers in Physiology 14, no. 8 (2017).
Status: Published
2016

Journal articles

S. Dewan, K. J. McCabe, M. Regnier, A. D. McCulloch and S. Lindert

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

The Journal of Physical Chemistry B 120, no. 33 (2016): 8264-8275.
Status: Published
2015

Journal articles

Y. Aboelkassem, J. A. Bonilla, K. J. McCabe and S. G. Campbell

Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function

Biophysical Journal 109, no. 10 (2015): 2101-2112.
Status: Published